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‘The avermectin family of compounds was discovered by Satoshi Ćmura of Kitasato University and William Campbell of Merck. In 1970, Ćmura isolated a strain of Streptomyces avermitilis from woodland soil near a golf course along the south east coast of Honshu, Japan. Ćmura sent the bacteria to William Campbell, who showed that the bacterial culture could cure mice infected with the roundworm Heligmosomoides polygyrus. Campbell isolated the active compounds from the bacterial culture, naming them “avermectins” and the bacterium Streptomyces avermitilis for the compounds’ ability to clear mice of worms (in Latin: a ‘without’, vermis ‘worms’). Of the various avermectins, Campbell’s group found the compound “avermectin B1” to be the most potent when taken orally. They synthesized modified forms of avermectin B1 to improve its pharmaceutical properties, eventually choosing a mixture of at least 80% 22,23-dihydroavermectin B1a and up to 20% 22,23-dihydroavermectin B1b, a combination they called “ivermectin”.’
https://en.wikipedia.org/wiki/Ivermectin#History
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